NIS/HFIP‐Mediated Synthesis of Indene‐Based β‐Iodoalkenyl Sulfides from Propargylic Sulfides
نویسندگان
چکیده
A tandem 1,3-sulfur migration followed by iodocyclization reaction of propargylic sulfides in the presence NIS HFIP has been developed to synthesize indene-based β-iodoalkenyl sulfides. The choice media is crucial promote reaction. proposed mechanism involving initial activation and favoring sulfur starting thioether via cationic intermediates experimentally supported. In addition, suitability selected as building blocks for subsequent C−C bond-forming reactions demonstrated.
منابع مشابه
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15 صفحه اولAu-catalyzed reaction of propargylic sulfides and dithioacetals.
Propargylic sulfides and dithioacetals are found to undergo similar transformations as propargylic carboxylates when catalyzed by AuCl or AuCl3, affording indene derivatives through pentannulation of aromatic rings. The reaction presumably involves Au carbene as the reactive intermediate.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2022
ISSN: ['1615-4169', '1615-4150']
DOI: https://doi.org/10.1002/adsc.202200613